Naslov (eng)

Correlation between mRNA expression of IL-1β, IL-8, TNFα, IL-6 and IL-10 in PBMCs and redox status parameters in GDM

Autor

Stevanović, Jovana
Vasiljević, Iva
Penezić, Ana
Mandić, Milica
Maglić, Dragana
Mandić-Marković, Vesna
Brkušanin, Miloš
Nedić, Olgica
Dobrijević, Zorana

Publisher

Opis (eng)

ABSTRACT Gestational diabetes mellitus (GDM) is characterized by chronic low-level inflammation and oxidative stress, both of which contribute to disease pathogenesis. Cytokines expressed in peripheral blood mononuclear cells (PBMCs) may reflect the inflammatory status associated with redox alterations. This study aimed to investigate the correlations between the expression of IL-1β, IL-8, TNFα, IL-6 and IL-10 in PBMCs and selected oxidative stress parameters in women with GDM. Redox status was assessed by measuring the activities of the antioxidant enzymes glutathione reductase (GR), superoxide dismutase (SOD) and catalase (CAT), serum thiol content, expression of NRF2, as well as protein carbonyl (PCO) levels and TBARS as markers of oxidative biomacromolecular damage.

Jezik

engleski

Datum

2026

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

Cytokines, redox status, GDM, SOD, protein carbonyl levels

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP