Naslov (eng)

Correlation between the expression of proinflammatory cytokine genes and immunomodulatory microRNAs miR-27a, miR-222 and miR-340 in peripheral blood mononuclear cells of women with gestational diabetes

Autor

Stevanović, Jovana
Vasiljević, Iva
Radojičić, Ognjen
Mandić, Milica
Maglić, Dragana
Mandić-Marković, Vesna
Miković, Željko
Nedić, Olgica
Dobrijević, Zorana

Publisher

Opis (eng)

ABSTRACT Continuous low-level inflammation (IFM) is a major contributory factor to development of severe pregnancy complications associated with gestational diabetes mellitus (GDM). Presence of IFM throughout the hyperglycemic pregnancy associates with disturbances in microRNA-related mechanisms, while inflammatory pathway-related genes are known targets of microRNAs dysregulated in GDM. Our aim was to evaluate the correlation between the expression of GDM related microRNAs (miR-27a, miR-222 and miR-340) and mRNA encoding proinflammatory cytokines IL-1β, IL-8, TNFα and IL6 in peripheral blood mononuclear cells (PBMCs) from women with GDM and healthy controls.

Jezik

engleski

Datum

2025

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

IL-1β, IL-8, IL-6, TNFα, miRNA

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP