Naslov (eng)

miR-146a-5p and miR-21-5p from extracellular vesicles as potential biomarkers in gestational diabetes

Autor

Stevanović, Jovana
Radojičić, Ognjen
Mitić, Ninoslav
Penezić, Ana
Robajac, Dragana
Šunderić, Miloš
Miljuš, Goran
Četić, Danilo
Mandić, Milica
Ardalić, Daniela
Mandić Marković, Vesna
Miković, Željko
Nedić, Olgica
Dobrijević, Zorana

Publisher

Opis (eng)

ABSTRACT Introduction: The importance of dysregulation of the anti-oxidative system as the driving force of severe damage and pregnancy complications in gestational diabetes (GDM) is well supported by numerous lines of evidence. MicroRNA-based regulatory mechanism demonstrate impairment associated with GDM, as well as disturbances related to the presence of (glyco)oxidative stress ((g)OS) interconnected with inflammation (IFM). Therefore, we hypothesized that microRNAs may act as potential sensors and/or effectors of (g)OS/IFM in GDM and we selected known (g)OS/IFM-associated microRNAs mir-146a-5p and miR-21-5p as candidates for GDM biomarker analysis. The aim was to assess the biomarker potential of these microRNAs from serum-derived extracellular vesicles (EVs).

Jezik

engleski

Datum

2024

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-ND 4.0 - Creative Commons Autorstvo - Nekomercijalno - Bez prerada 4.0 International License.

http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode

Predmet

miR-146a-5p, miR-21-5p, extracellular vesicles, oxidative stress, inflammation

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP