Analysis of glycan changes in gestational diabetes mellitus
Pažitná, Lucia
Kianičková, Kristína
Kundalia, Paras H.
Dobrijević, Zorana
Gligorijević, Nikola
Miljuš, Goran
Penezić, Ana
Robajac, Dragana
Šunderić, Miloš
Nedić, Olgica
Mandić Marković, Vesna
Radojičić, Ognjen
Miković, Željko
Katrlík, Jaroslav
ABSTRACT One of the main types of diabetes is gestational diabetes mellitus (GDM). The sooner this condition is diagnosed, the sooner it can be treated. Glycan changes appear as possible way how to distinguish diabetes type 1 from type 2 (1). Based on that, we focused on the glycan changes during GDM. We compared serum, plasma, fibrinogen and platelets samples of healthy pregnant women and women with GDM. Samples were analysed using lectin-based microarray method (2). Found differences in glycan composition can play important role for identification of potential biomarkers, which can be useful in research and diagnostics.
engleski
2022
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Gestational diabetes mellitus, glycan changes, lectin-based microarray method