Naslov (eng)

Identification and functional characterization of tumor-suppressive microRNAs with potential key roles in breast cancer progression and metastasis

Autor

Nikezić, Aleksandra
Dobrijević, Zorana
Goč, Sanja
Nedić, Olgica
Brkušanin, Miloš
Stevanović, Jovana
Jovankić, Jovana

Publisher

Opis (eng)

ABSTRACT Downregulation of tumor-suppressive microRNAs in breast cancer (BC) triggers molecular disturbances underlying cancer initiation, disease progression and metastasis. However, key microRNAs players acting as vital breaks on BC aggressiveness, with crucial regulatory roles in cell migration, epithelial-mesenchymal transition (EMT), invasion, and metas-tasis, remain underinvestigated. Our goal was to uncover candidate tumor-suppresive microRNAs associated with metastatic potential of BC via an in silico approach, which combined data from microRNA profiling studies on cell lines relevant to BC invasiveness, as well as on primary vs. metastatic BC. A minimal set of candidate microRNAs was determined from the intersection of downregulated sets from multiple eligible studies, confirmed by qPCR, assessed for potential clinical relevance in BC and functionally characterized. Predicted and experimentally validated targets of these microRNAs were identified (MiRTargetLink) and subjected to gene ontology (GO), KEGG pathway, and cancer hallmark enrichment analysis.

Jezik

engleski

Datum

2026

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-ND 4.0 - Creative Commons Autorstvo - Nekomercijalno - Bez prerada 4.0 International License.

http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode

Predmet

microRNAs, invasion, EMT, metastasis, BRCA

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP