Naslov (eng)

Thyroid-Originating Extracellular Vesicles Harbor Thyroid-Specific Biomarkers with Potential Relevance for Thyroid Cancer Recurrence Detection

Autor

Bobar, Nevena
Mitić, Ninoslav
Kosanović, Maja
Šelemetjev, Sonja
Išić Denčić, Tijana
Taušanović, Katarina
Janković Miljuš, Jelena

Publisher

Opis (eng)

ABSTRACT Thyroid cancer (TC) is the most common endocrine malignancy, and challenges persist in preoperative diagnosis of indeterminate nodules and postoperative monitoring when thyroglobulin (Tg) assays are compromised by interfering anti-Tg antibodies (Tg-Ab). Extracellular vesicles (EVs) carry molecular cargo reflective of cells of origin and are increasingly explored as biomarker sources. In this study, we investigated whether thyroid derived EVs retain the expression of thyroid-specific thyrotropin-receptor (TSHR), a suitable target in immunoaffinity-based EV isolation, and explored the presence of Tg in EV cargo as potential surrogate for serum Tg.

Jezik

engleski

Datum

2026

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

extracellular vesicles; thyroid cancer; recurrent thyroid cancer; thyrotropin-receptor; TSHR; thyroglobulin; thyroid cell lines; human plasma

Deo kolekcije (1)

o:25140

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