Naslov (eng)

Strawberry Fragaria x ananassa Duchesne (cv. Romina) methanolic extract attenuates hydrogen peroxide induced DNA damage in human peripheral blood mononuclear cells in vitro

Autor

Živković, Lada
Pirković, Andrea
Topalović, Dijana
Giampieri, Francesca
Armas Diaz, Yasmany
Milić, Mirta
Spremo-Potparević, Biljana

Publisher

Opis (eng)

ABSTRACT Among berry fruits, strawberries are known for a wide array of beneficial biological activities, including antioxidant, antihypertensive, antibacterial, anti-proliferative, anti-inflammatory, anticancer, and anti-metastatic effects. The cultivar Fragaria × ananassa Duchesne (Romina) is particularly rich in bioactive constituents that may contribute to limiting DNA damage triggered by reactive oxygen species. In this study, we examined whether the methanolic extract of Romina strawberries (RE) exerted any genotoxic effect on human peripheral blood mononuclear cells (PBMCs) across concentrations ranging from 25 to 200 μg/mL using the comet assay. No evidence of genotoxicity was detected. Subsequently, the capacity of RE to counteract oxidative DNA damage in two experimental models was assesed. When PBMCs were pretreated with RE prior to hydrogen peroxide exposure, a slight reduction in DNA damage was observed, with only the 50 μg/mL concentration producing a statistically significant protective effect.

Jezik

engleski

Datum

2026

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC 4.0 - Creative Commons Autorstvo - Nekomercijalno 4.0 International License.

http://creativecommons.org/licenses/by-nc/4.0/legalcode

Predmet

ageing , comet assay, DNA damage, neurodegenerative disease

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP