Naslov (eng)

Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging

Autor

Briganti, Stefania
Camera, Emanuela
Ciriza, Jesús
Fernandez Carro, Estibaliz
Jovanović Krivokuća, Milica
Lamartine, Jerome
Letsiou, Sophia
Nacka-Aleksić, Mirjana
Niessen, Carien M
Oliva, Núria
Pirković, Andrea
Schosserer, Markus
Tobin, Desmond J
Cavinato, Maria
Connelly, John T

Publisher

Opis (eng)

ABSTRACT With age, human skin undergoes a progressive decline in essential functions, including barrier protection, immunity, and wound healing capacity, which underlie many age-related skin diseases. Skin aging is not only driven by chronological aging, but also strongly influenced by extrinsic stressors, notably ultraviolet radiation, pollutants, and diet. Thus, understanding the complex interplay between these intrinsic and extrinsic factors is essential for developing strategies to preserve skin health across the lifespan. Given the growing appreciation for the physiologic differences between humans and animal models, more advanced in vitro and ex vivo models are needed to dissect the human-specific mechanisms of skin aging and test emerging therapies. In this review, we summarize the major hallmarks of human skin aging and provide an overview of current in vitro modeling approaches that capture both intrinsic and environmental aging mechanisms.

Jezik

engleski

Datum

2026

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

Aging; Human skin; In vitro models; Organotypic; Senescence; Skin equivalent

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP