Naslov (eng)

Comparative Characterization of Non-Treated and UV-Irradiated Bilberry Leaf Extract-Loaded Liposomes Physicochemical Properties, Stability, and Antioxidant Capacity

Autor

Jovanović, Aleksandra A.
Pirković, Andrea
Milošević, Milena
Elferjane, Muna
Marinković, Aleksandar
Dekanski, Dragana

Publisher

Opis (eng)

Vaccinium myrtillus L. (European bilberry) leaves are rich in phenolic acids, flavonoids, and anthocyanins. To improve the stability, bioavailability, and controlled release of these bioactives, bilberry leaf extract was encapsulated in liposomes using proliposome technology. The study compared non-treated and UV-irradiated liposomal systems, evaluating encapsulation efficiency (EE), FT-IR spectra, physical properties, and antioxidant activity. FT-IR results indicated that lipid bands dominated the spectra, masking extract-specific bands. Antioxidant activity remained stable post-UV treatment, with ABTS and DPPH inhibition values of 53.17% and 68.71%, respectively. Over a 60-day period, liposomes maintained narrow size distributions (5169.7–5508.7 nm), with zeta potential ranging from −5.02 mV to −9.16 mV and polydispersity index between 0.294–0.437. UV irradiation had a minimal impact on physicochemical or antioxidant characteristics. These findings highlight the potential of liposomal delivery systems for bilberry leaf extract in various applications, with an additional need to improve system stability, i.e., increase zeta potential.

Jezik

engleski

Datum

2026

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-SA 4.0 - Creative Commons Autorstvo - Nekomercijalno - Deliti pod istim uslovima 4.0 International License.

http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode

Predmet

bilberry, extract, liposomes, particle size, stability, zeta potential

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP