Naslov (eng)

Upregulation of the Antioxidant Response-Related microRNAs miR-146a-5p and miR-21-5p in Gestational Diabetes: An Analysis of Matched Samples of Extracellular Vesicles and PBMCs

Autor

Stevanović, Jovana
Mitić, Ninoslav
Penezić, Ana
Radojičić, Ognjen
Ardalić, Daniela
Mandić, Milica
Mandić-Marković, Vesna
Miković, Željko
Brkušanin, Miloš
Nedić, Olgica
Dobrijević, Zorana

Publisher

Opis (eng)

ABSTRACT MicroRNA-based regulatory mechanisms show disturbances related to oxidative stress (OS) interconnected with inflammation (IFM), as well as impairments associated with gestational diabetes (GDM). The aim of this study was to assess the diagnostic and prognostic significance of the OS/IFM-related microRNA in GDM by using peripheral blood mononuclear cells (PBMCs) and serum-derived extracellular vesicles (EVs) as biological samples. We selected the known OS/IFM-associated microRNAs miR-146a-5p, miR-155-5p, and miR-21-5p as candidates for our GDM biomarker analysis.

Jezik

engleski

Datum

2025

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

miR-21-5p; miR-155-5p; miR-146a-5p; oxidative stress; redox status; gestational diabetes; iron; superoxide dismutase; adverse outcomes

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP