Trophoblast Extracellular Vesicles as Modulators of Keratinocyte Stress Response and Senescence
Legner, Janko
Pirković, Andrea
Dekanski, Dragana
Vilotić, Aleksandra
Nacka-Aleksić, Mirjana
Kosanović, Maja
Jovanović Krivokuća, Milica
ABSTRACT Keratinocyte stress, caused by various intrinsic and extrinsic factors, contributes to the overall aging process. D-galactose-induced metabolic/oxidative stress is a commonly used in vitro model for studying premature aging. Due to their rich composition of bioactive molecules that influence critical pathways in cellular aging and rejuvenation, placental derivatives have a well- established history in anti-aging skincare and therapy. However, trophoblast-derived extracellular vesicle (TEV) effects on D-galactose-induced premature aging in keratinocytes have not been investigated yet.
engleski
2025
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Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.
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skin; aging; placenta; wound healing; regenerative medicine