Naslov (eng)

Human Monocytes Exposed to SARS-CoV-2 Display Features of Innate Immune Memory Producing High Levels of CXCL10 upon Restimulation

Autor

Cvetković, Jelena
Jacobi, Ronald H.J.
Miranda-Bedate, Alberto
Pham, Nhung
Kutmon, Martina
Groot, James
van de Garde, Martijn D.B.
Pinelli, Elena

Publisher

Opis (eng)

ABSTRACT Introduction: A role for innate immune memory in protection during COVID-19 infection or vaccination has been recently reported. However, no study so far has shown whether the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can train innate immune cells. The aim of this study was to investigate whether this virus can induce trained immunity in human monocytes. Methods: Monocytes were exposed to inactivated SARS-CoV-2 (iSARS-CoV-2) for 24 h, followed by a resting period in the medium only and a secondary stimulation on day 6 after which the cytokine/chemokine and transcriptomic profiles were determined.

Jezik

engleski

Datum

2023

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC 4.0 - Creative Commons Autorstvo - Nekomercijalno 4.0 International License.

http://creativecommons.org/licenses/by-nc/4.0/legalcode

Predmet

Trained immunity, Severe acute respiratory syndrome coronavirus 2, CXCL10, Monocytes

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP