Naslov (eng)

miR-27a-3p, miR-222-3p and miR-340-5p as indicators of the antioxidant response activation in gestational diabetes

Autor

Penezić, Ana
Ardalić, Daniela
Mandić-Marković, Vesna
Miković, Željko
Nedić, Olgica
Dobrijević, Zorana
Šunderić, Miloš
Miljuš, Goran
Robajac, Dragana
Stevanović, Jovana
Radojičić, Ognjen

Publisher

Opis (eng)

ABSTRACT Background: Gestational diabetes (GDM) is the most common pregnancy related metabolic disorder and a major risk factor for both mother and a child, during pregnancy and after delivery. Impairment of the anti-oxidative system acts as the driving force of the devastating consequences in GDM, while microRNA molecules are affected by disturbances related to (glyco)oxidative stress ((g)OS) and emerged as potential sensors and effectors of (g)OS-associated mechanisms. Aims: The aim of the present study was to evaluate the potential of OS-related microRNAs miR-27a, miR222 and miR-340 from peripheral blood mononuclear cells (PBMCs) to serve as OS indicators of in GDM.

Jezik

engleski

Datum

2025

Licenca

© All rights reserved

Predmet

microRNA; pregnancy; glutathione reductase; thiol content; Superoxide dismutase; zinc

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP