Naslov (eng)

Stability of Cotinus coggygria Scop. Extract-Loaded Liposomes: The Impact of Storage on Physical and Antioxidant Properties

Autor

Jovanović, Aleksandra A.
Karkad, Amjed
Pirković, Andrea
Dekanski, Dragana
Lupulović, Diana
Novaković, Miroslav
Marinkovic, Aleksandar

Publisher

Opis (eng)

The stability of Cotinus coggygria extract-loaded liposomes (non-treated and UV irradiated) was determined after 60 days through an investigation of the impact of storage on liposomal physical and antioxidant properties. The liposome size varied in a narrow range for 60 days; PDI was 0.273–0.313 (non-treated) and 0.829–0.911 (UV-irradiated). The zeta potential ranged from −28.2 to −29.6 mV (non-treated) and from −21.5 to −22.0 mV (UV-irradiated). The obtained liposomes with the extract neutralized 81.9% of free DPPH radicals before UV irradiation and 80.9% after irradiation. In the ABTS assay, UV irradiation also significantly reduced the antioxidant capacity, from 12.02 to 10.55 µmol Trolox equivalent (TE)/mL. The ABTS and DPPH radical scavenging activity of the UV-irradiated liposomes significantly decreased after the 60-day storage (8.93 µmol TE/mL and 75.4%, respectively), whereas in the non-treated sample, the mentioned drop in antioxidant capacity was not noticed. Liposomal formulations of C. coggygria extract can exhibit significant potential for further development as a functional food or dermo-cosmetic ingredient.

Jezik

engleski

Datum

2025

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

liposomes; storage stability; antioxidant capacity; Cotinus coggygria; extract

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP