Naslov (eng)

Intranasal application of Trichinella spiralis muscle larvae extracellular vesicles alleviate inflammation in mouse model of respiratory allergy

Autor

Glamočlija, Sofija
Schmid, Anna
Radulović, Nataša
Gruden-Movsesijan, Alisa
Sabljić, Ljiljana
Schabussova, Irma
Kosanović, Maja

Publisher

Opis (eng)

ABSTRACT Introduction: The parasitic helminth, the nematode Trichinella spiralis, affects the host immune system through its excretory-secretory products (ES L1), which contain extracellular vesicles (EVs) that prevent host immune response to itself and also the development of chronic inflammatory diseases in the host. EVs from T. spiralis muscle larvae (TsEVs) have been shown to exert immunomodulatory properties on human dendritic cells, inducing a stable tolerogenic phenotype and eliciting regulatory T cells (Treg). Furthermore, it has been shown that infection with T. spiralis can alleviate allergic airway inflammation in mice. Therefore, the aim of this work was to investigate whether TsEVs alone have the same effect.

Jezik

engleski

Datum

2024

Licenca

© All rights reserved

Predmet

extracellular vesicles, Trichinella spiralis

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP