Naslov (eng)

Interactions of Trichinella spiralis mucle larvae extracellular vesicles with target cells and their mechanisms of action

Autor

Glamočlija, Sofija
Schmid, Anna
Gruden-Movsesijan, Alisa
Djokić, Jelena
Schabussova, Irma
Kosanović, Maja

Publisher

Opis (eng)

ABSTRACT Introduction: The parasite Trichinella spiralis induces a tolerogenic immune microenvironment in its host, which also leads to the alleviation of chronic inflammatory diseases. This effect is exerted by excretory–secretory products of the muscle larvae (ES L1), with extracellular vesicles (TsEVs) being one of their most active components. TsEVs have been shown to induce a stable tolerogenic phenotype of human monocyte-derived dendritic cells (hDC), which are then able to induce regulatory T cells (Treg). It has also been shown that TsEVs can alleviate allergic airway inflammation in a mouse model. However, themechanisms of action TsEVs underlying the observed effects are still unknown. Therefore, the aim of this study was to investigate how TsEVs interact with human cells and whichsignalling pathways they employ.

Jezik

engleski

Datum

2024

Licenca

© All rights reserved

Predmet

Trichinella spiralis, extracellular vesicles, ES L1

Deo kolekcije (1)

o:25140

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