Naslov (eng)

Investigating the effect of extracellular vesicles from Trichinella spiralis on reduction of respiratory allergy induced by ovalbumin in BALB/c mice

Autor

Kosanović, Maja
Glamočlija, Sofija
Schmid, Anna
Radulović, Nataša
Gruden-Movsesijan, Alisa
Sabljić, Ljiljana
Vasilev, Saša
Schabussova, Irma

Publisher

Opis (eng)

ABSTRACT Introduction: We have recently discovered that extracellular vesicles from Trichinella spiralis muscle larvae (TsEVs) exhibit immunomodulatory properties in vitro. Our goal was to investigate the potential of TsEVs to ameliorate ovalbumin (OVA)-induced allergy in a murine model. Material & Methods: Experimental allergic airway inflammation was induced in BALB/c mice. Treatment by intranasal administration of TsEVs was performed on the days of sensitization and challenge. Cells from bronchoalveolar lavage, lungs and speen were stained and analyzed by FACS or cultivated for cytokine analysis. Results: TsEVs treatment led to a significant reduction in the OVA-specific IgE in the sera, decrease in number of eosinophils in the bronchoalveolar lavage and decline in percentage of eosinophils, macrophages and NK cells in the lungs of treated animals.

Jezik

engleski

Datum

2024

Licenca

© All rights reserved

Predmet

Trichinella spiralis muscle larvae (TsEVs), BALB/c mice, respiratory allergy

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP