Naslov (eng)

Clinical Prospect of Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles in Kidney Disease: Challenges and the Way Forward

Autor

Kosanović, Maja
Milutinović, Bojana
Kutzner, Tanja J.
Mouloud, Yanis
Božić, Milica

Publisher

Opis (eng)

ABSTRACT Kidney disease is a growing public health problem worldwide, including both acute and chronic forms. Existing therapies for kidney disease target various pathogenic mechanisms; however, these therapies only slow down the progression of the disease rather than offering a cure. One of the potential and emerging approaches for the treatment of kidney disease is mesenchymal stromal/stem cell (MSC) therapy, shown to have beneficial effects in preclinical studies. In addition, extracellular vesicles (EVs) released by MSCs became a potent cell-free therapy option in various preclinical models of kidney disease due to their regenerative, anti-inflammatory, and immunomodulatory properties. However, there are scarce clinical data available regarding the use of MSC-EVs in kidney pathologies. This review article provides an outline of the renoprotective effects of MSC-EVs in different preclinical models of kidney disease.

Jezik

engleski

Datum

2023

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

mesenchymal stromal/stem cells; extracellular vesicles; kidney disease; acute kidney injury; chronic kidney disease; transplantation; renoprotection; cell-free therapeutics; mechanism of action; clinical application

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP