Naslov (eng)

Do extracellular vesicles from Trichinella spiralis muscle larvae harbor the potential to induce regulatory T cells?

Autor

Sabljić, Ljiljana
Tomić, Sergej
Sofronić-Milosavljević, Ljiljana
Glamočlija, Sofija
Ilić, Nataša
Gruden-Movsesijan, Alisa
Kosanović, Maja

Publisher

Opis (eng)

ABSTRACT During the chronic phase of the infection, Trichinella spiralis, through its excretory-secretory products (ES L1), induce Th2 and regulatory immune responses, thus creating nonpermissive environment for the development of autoimmune and other chronic inflammatory diseases. Our major goal is to discover immunomodulatory components within ES L1 products, so that we can characterize them and use them to design treatment for humans. Extracellular vesicles, isolated from T. spiralis ES L1 products (TsEVs), may be the important players in initiation, progression and regulation of the immune response, via their impact on dendritic cells. Human monocyte derived dendritic cells (DCs) were treated with TsEVs and subsequently co-cultivated with allogenic T cells.

Jezik

engleski

Datum

2023

Licenca

© All rights reserved

Predmet

Trichinella spiralis, extracellular vesicles, regulatory T cells

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP