Naslov (eng)

Can we use Trichinella spiralis muscle larvae extracellular vesicles for the treatment of allergic airway inflammation?

Autor

Glamočlija, Sofija
Kosanović, Maja
Schabussova, Irma
Vasilev, Saša
Sabljić, Ljiljana
Gruden-Movsesijan, Alisa
Ilić, Nataša
Schmid, Anna

Publisher

Opis (eng)

ABSTRACT Extracelular vesicles (EVs) are a fundamental way of communication between cells of one organism but also between different organisms and even different species. These nano-sized membrane-limited biological particles, carry information in the form of proteins, lipids, RNA, as well as other molecules, and deliver them to target cells, thus playing role in all physiological and pathophysiological processes in an organism. We have recently discovered that extracellular vesicles isolated from Trichinella spiralis excretory-secretory products (TsEVs) exert immunomodulatory properties on human monocyte derived dendritic cells. It was previously shown that T. spiralis infection alters immune response and exerts beneficial effect in mice with allergic airway inflammation. Our goal was to investigate the potential of TsEVs to ameliorate ovalbumin (OVA)-induced allergy in a murine model. Experimental allergic airway inflammation was induced in BALB/c mice by intraperitoneal injection of OVA in alum. On days 21-24 mice were challenged with intranasal application of OVA.

Jezik

engleski

Datum

2023

Licenca

© All rights reserved

Predmet

Trichinella spiralis, extracellular vesicles, allergy

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP