Naslov (eng)

Immunomodulation by extracellular vesicles from Trichinella spiralis muscle larvae: increasing tolerogenic properties of human dendritic cells

Autor

Glamočlija, Sofija
Kosanović, Maja
Sofronić-Milosavljević, Ljiljana
Tomić, Sergej
Sabljić, Ljiljana
Gruden-Movsesijan, Alisa
Ilić, Nataša

Publisher

Opis (eng)

ABSTRACT Excretory-secretory products (ES) of parasitic worms (helminths) shift hosts’ immunological balance toward Th2 and regulatory responses thus acting beneficial in chronic inflammations, i.e. autoimmune diseases. As shown in several helminths, extracellular vesicles (EVs) are active immunomodulatory component of ES.We found that Trichinella spiralis produces EVs (TsEVs) which influence cytokine production by PBMC. Now we aim to show how TsEVs influence human dendritic cells (DC), as key players in initiation, progression and regulation of immune response.

Jezik

engleski

Datum

2021

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

TsEVs, autoimmune diseases, extracellular vesicles, Trichinella spiralis

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP