Naslov (eng)

ETS1 Protein Expression May Be Altered by the Complementarity of ETS1 mRNA Sequences with miR-203a-3p and miR-204-3p in Papillary Thyroid Carcinoma

Autor

Stojanović Novković, Stefana
Šelemetjev, Sonja
Janković Miljuš, Jelena
Živaljević, Vladan
Dundjerović, Duško
Milinković, Marija
Išić Denčić, Tijana

Publisher

Opis (eng)

ABSTRACT The expressions of ETS1, miR-203a-3p, and miR-204-3p in papillary thyroid carcinoma (PTC) are poorly described, and their clinical significance is unclear. To determine the prognostic value of ETS1 (E26 transformation-specific), its levels in divergent cell compartments were paired with miR-203a-3p/-204-3p levels and linked to the presence of unfavorable clinical characteristics of PTC patients. Immunohistochemistry and Western blot were performed to evaluate ETS1 protein expression in PTC and matched nonmalignant thyroid tissue (NMT). qPCR was utilized to quantify ETS1 mRNA, miR-203a-3p, and miR-204-3p expressions. Bioinformatic analysis was applied to predict biological interactions.

Jezik

engleski

Datum

2025

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

PTC; miRNA; cancer biomarker; prognostic factor; microRNA; subcellular localization

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP