Naslov (eng)

Bioactivity Assessment of Functionalized TiO2 Powder with Dihydroquercetin

Autor

Nikšić, Valentina
Pirković, Andrea
Spremo-Potparević, Biljana
Živković, Lada
Topalović, Dijana
Nedeljković, Jovan M.
Lazić, Vesna

Publisher

Opis (eng)

ABSTRACT Biological activities, including cell viability, oxidative stress, genotoxicity/antigenotoxicity, and antimicrobial activity, were evaluated for a visible-light-responsive TiO2-based ICT complex with dihydroquercetin (DHQ) and compared with pristine TiO2, its inorganic component. Pristine TiO2 did not induce cytotoxicity in MRC-5 or HeLa cells within the tested concentration range (1–20 mg/mL), while TiO2/DHQ displayed a significant reduction in cell viability in both cell lines at higher concentrations (≥10 mg/mL). The analysis of reactive oxygen species (ROS) production revealed that TiO2/DHQ significantly reduced ROS levels in both cell types (MRC-5 and HeLa), with HeLa cells showing a more substantial reduction at lower concentrations.

Jezik

engleski

Datum

2025

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

TiO2; dihydroquercetin; interfacial charge transfer complex; cytotoxicity; antigenotoxicity; antimicrobial activity

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP