Naslov (eng)

Cytotoxic, Antioxidant, and Anti-Genotoxic Properties of Combretastatin A4 in Human Peripheral Blood Mononuclear Cells: A Comprehensive In Vitro Study

Autor

Popović, Petar
Pirković, Andrea
Topalović, Dijana
Živković, Lada
Marković, Milica
Spremo-Potparević, Biljana

Publisher

Opis (eng)

ABSTRACT Despite significant advances in drug discovery and the promising antitumor potential of combretastatin A4 (CA-4), which selectively targets rapidly dividing cancer cells, CA-4’s effects on non-dividing human cells, such as peripheral blood mononuclear cells (PBMCs), remain unclear. The aim of this study is to evaluate the in vitro bioactivity of CA-4 in human PBMCs, focusing on its antigenotoxic and antioxidant properties, while comparing its cytotoxic potency against PBMCs, cancer cell lines (JAR and HeLa), and the normal trophoblast cell line HTR 8/SVneo. Cell viability and metabolic activity were evaluated using the MTT assay.

Jezik

engleski

Datum

2024

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

combretastatin A4; PBMC; oxidative stress; genotoxicity; trophoblast

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP