Naslov (eng)

Association between genetic variants in HSA-MIR-27A and HSA-MIR-146A genes and male infertility

Autor

Rajovski, Srećko
Milanović, Nikoleta
Radovanović, Nemanja
Brkušanin, Miloš
Savić-Pavićević, Dušanka
Dobrijević, Zorana
Brajušković, Goran
Matijašević Joković, Suzana

Opis (eng)

ABSTRACT Background: miRNAs have enormous potential to be used as diagnostic and prognostic markers as well as therapeutic targets in male infertility and diseases of the reproductive system. This study aimed to investigate the association between the two functional genetic variants in the hsa-miR27a (rs2910164) and hsa-miR-146a gene (rs895819) and male infertility in North Macedonian population, as well as to test their association with the values of major seminal parameters. Methods: The case group included in this study comprised 158 men initially diagnosed with idiopathic male infertility. The control group included 126 age-matched healthy male volunteers who fathered at least one child. Results: We report the association of rs2910164 minor allele C for the first time with the increased susceptibility to asthenoteratozoospermia. Additionally, our results indicating the association of allele C with low sperm vitality are a novel finding. We did not demonstrate the association between genetic variant rs895819 and the risk of different types of male infertility. Still, the number of participants with CC genotype in subjects diagnosed with asthenoteratozoospermia was null, while in controls, it reached 7.2%. We further detected the rs895819 genotype-dependent difference in rapid progressive sperm motility.

Jezik

engleski

Datum

2024

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

male infertility, rs2910164, rs895819, polymorphism, miR-27a, miR-146a

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP