Naslov (eng)

Bioactivity of methanolic pulp extract from pumpkin (Cucurbita moschata) in human keratinocytes

Autor

Pirković, Andrea
Krstić, Sanja
Jovanović, Aleksandra
Dekanski, Dragana
Miljić, Milorad

Publisher

Opis (eng)

ABSTRACT The study investigated the potential of pumpkin pulp extracts from two Cucurbita moschata accessions grown in Serbia as skin-friendly agents with antioxidant and sun protecting properties. The research aimed to address the underrepresentation of pumpkin pulp in bioactivity studies despite its potential as a rich source of beneficial compounds for skin health. Methanolic pumpkin pulp extracts (MPE) were prepared from two accessions, MO 31 and MO 32, sourced from the breeding collection of the Institute of Field and Vegetable Crops in Novi Sad, Serbia. The MPE were characterized for their carotenoid content using HPLC-DAD, revealing different levels of carotenoids in each accession. Cumulative carotenoid content in MO 31 and MO 32 was 0.29 and 0.09 mg/g, respectively. The cytotoxicity of the extracts was assessed using viability assay MTT in human keratinocyte (HaCaT) cells, and showed no significant decrease in cell viability at concentrations of 10, 100, and 1000 μg/mL after 24 hours of exposure.

Jezik

engleski

Datum

2024

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-ND 4.0 - Creative Commons Autorstvo - Nekomercijalno - Bez prerada 4.0 International License.

http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode

Predmet

pumpkin extract, keratinocytes, skin, bioactivity, reactive oxygen species, cytotoxicity, photoprotective

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP