Naslov (eng)

Diagnostic significance of miR-146a, miR-21 and miR-155 from PBMCs in gestational diabetes

Autor

Stevanović, Jovana
Radojičić, Ognjen
Penezić, Ana
Robajac, Dragana
Šunderić, Miloš
Miljuš, Goran
Četić, Danilo
Ardalić, Daniela
Mandić, Milica
Mandić Marković, Vesna
Miković, Željko
Nedić, Olgica
Dobrijević, Zorana

Publisher

Opis (eng)

ABSTRACT MicroRNA-based mechanisms are heavily dysregulated in disorders of glucose metabolism, including gestational diabetes (GDM) and its common successor, type 2 diabetes mellitus. Since oxidative stress (OS) and the interconnected low-level inflammation (IFM) accompany GDM and the associated pregnancy complications, we selected known OS/IFM-related microRNAs as candidates for a study on biomarker properties in GDM. The aim of the conducted research was to evaluate the diagnostic and prognostic significance of miR-146a-5p, miR-155-5p and miR-21-5p from peripheral blood mononuclear cells (PBMCs), as well as their potential as indicators of glucose and lipid status in the second/early third pregnancy trimester.

Jezik

engleski

Datum

2024

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-ND 4.0 - Creative Commons Autorstvo - Nekomercijalno - Bez prerada 4.0 International License.

http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode

Predmet

miR-146a-5p, miR-21-5p, mir-155-5p, PBMC, oxidative stress, redox status

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP