Naslov (eng)

TAXIFOLIN MODULATES mRNA EXPRESSION OF INVASION-ASSOCIATED MARKERS AND STIMULATES MIGRATION OF HUMAN TROPHOBLAST CELLS

Autor

Vilotić, Aleksandra
Pirković, Andrea
Spremo Potparević, Biljana
Bojić-Trbojević, Žanka
Bruić, Marija
Jovanović Krivokuća, Milica

Publisher

Opis (eng)

ABSTRACT During first trimester of pregnancy, the specific regulation of extravillous trophoblast migration and invasion into the maternal uterine wall is essential for successful placental development. Taxifolin (TAX) is a flavonoid of strong antioxidant activity that recently showed cytoprotective effects in trophoblast cells. The aim was to investigate if TAX can affect cell adhesion and migration in HTR- 8/SVneo extravillous trophoblast cells as well as the expression of molecules that mediate these processes. Concentrations of TAX 10 and 100 μM were selected according to the previously reported cytoprotective effects.

Jezik

engleski

Datum

2024

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-ND 4.0 - Creative Commons Autorstvo - Nekomercijalno - Bez prerada 4.0 International License.

http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode

Predmet

taxifolin, trophoblast, integrins, matrix metalloproteinases, cell migration

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP