Naslov (eng)

Oleuropein treatment attenuates ROS generation, inflammation, and H2O2-induced damage in human trophoblast cells

Autor

Vilotić, Aleksandra
Bojić-Trbojević, Žanka
Pirković, Andrea
Dekanski, Dragana
Nacka-Aleksić, Mirjana
Jovanović Krivokuća, Milica

Publisher

Opis (eng)

ABSTRACT Higher energy demands during pregnancy lead to enhanced oxidative phosphorylation and increased production of reactive oxygen species (ROS) which have been shown to act as important regulators of angiogenesis, proliferation, differentiation and invasion of placental cells-trophoblast, autophagy and other important physiological processes and tissue adaptations. This controlled placental oxidative stress and inflammatory response are essential for successful early pregnancy. However, unbalanced, excessive ROS production has adverse effects on pregnancy outcome, causing trophoblast cell damage and dysfunction. Antioxidant supplements have been proposed as a possible approach in the prevention and treatment of such disorders.

Jezik

engleski

Datum

2024

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-ND 4.0 - Creative Commons Autorstvo - Nekomercijalno - Bez prerada 4.0 International License.

http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode

Predmet

human trophoblast cells, reactive oxygen species (ROS), oleuropein (OLE)

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP