Naslov (eng)

Detecting thyrotropin receptor mRNA from peripheral blood of patients with differentiated thyroid cancer rules out non-aggressive cases

Autor

Janković Miljuš, Jelena
Prosenc Zmrzljak, Uršula
Košir, Rok
Jovanović, Milan
Đorić, Ilona
Rončević, Jelena
Išić Denčić, Tijana
Šelemetjev, Sonja

Publisher

Opis (eng)

ABSTRACT Early diagnosis of thyroid cancer is hampered by the inability of fine-needle aspiration biopsy (FNAB) to accurately classify ∼30% of cases while preoperative cancer staging detects lymph nodal involvement in only half of cases. Liquid biopsy may present an accurate, non-invasive alternative for preoperative thyroid nodule assessment. Thyrotropin receptor (TSHR) mRNA, a surrogate marker for circulating cancer cells (CTC), may be an option for early detection of malignancy from peripheral blood, but requires methodological improvements. We aimed to investigate if TSHR mRNA can be detected in low sample volumes by employing an ultrasensitive method-droplet digital PCR (ddPCR).

Jezik

engleski

Datum

2024

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-ND 4.0 - Creative Commons Autorstvo - Nekomercijalno - Bez prerada 4.0 International License.

http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode

Predmet

Circulating tumour cells, droplet digital PCR, liquid biopsy, thyroid cancer, thyrotropin receptor mRNA

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP