Naslov (eng)

Anticancer effects of non-toxic repurposed drugs on hamster fibrosarcoma – fast applicable in oncology

Autor

Popović J., Kosta
Popović J., Dušica
Dolićanin, Zana
Miljković, Dejan
Lalošević, Dušan
Popović K., Jovan
Čapo, Ivan

Opis (eng)

Abstract: Background. Some drugs developed for other illnesses might be repurposed for cancer treatment, to kill cancer cells by hitting previously recognized or unrecognized molecular target or unknown target. This study investigated such drugs, with proven in vitro anticancer effects, in vivo on fibrosarcoma in hamsters. Material and Methods. Anticancer efficacy of selected repurposed drugs: mebendazole, metformin, diclofenac, 2-Deoxy-D-glucose, deoxycholic acid, caffeine, itraconazole, nitroglycerin, disulfiram and selected two-component combinations were tested on fibrosarcoma experimentally induced by BHK-21/C13 cells in Syrian golden hamsters. Tumor biophysical characteristics, histology and immunohistochemistry were assessed. Blood samples were collected for hematological and biochemical analyses and the main organs were toxicologically analyzed. Results. This study showed that two-drug combinations: metformin with 2-Deoxy-D-glucose, metformin with deoxycholic acid, metformin with caffeine, metformin with itraconazole, metformin with nitroglycerin and metformin with disulfiram can significantly (P < 0.05) suppress fibrosarcoma in hamsters with doses equivalent to achievable oncological human doses, without toxicity and influence on biochemical and hematological tests. Conclusion. All efficacious repurposed drug combinations recorded in our study on hamster fibrosarcoma can be recommended for further clinical trials.

Jezik

engleski

Datum

2023

Licenca

© All rights reserved

Predmet

Keywords : BHK-21/C13, cell culture, drug combinations, drug effects, fibrosarcoma, hamsters

Deo kolekcije (1)

o:28516

Radovi nastavnika i saradnika Državnog univerziteta u Novom Pazaru