Naslov (eng)

Repurposed drug combinations that efficaciously inhibit fibrosarcoma induced by BHK-21/C13 in hamsters

Autor

Dolićanin, Zana
Popović, Dušica J.
Popović, Kosta J.
Čapo, Ivan
Lalošević, Dušan
Popović, Jovan K.
Miljković, Dejan

Opis (eng)

Abstract: A large diversity in molecular mechanisms of cancer regulation allows some marketed pleiotropic non-oncological non-toxic pharmaceuticals to be used in oncology, what reduce duration and cost of novel anticancer treatment research. By docking data of biomolecular activities of nontoxic non-oncological drugs with anticancer targets, we have chosen some promising combinations for further screening on fibrosarcoma in hamsters and separated combinations for possible use in oncology. For each repurposed drug – component of efficacious combination, identification of known anticancer mechanisms was found in the literature and jointly compared.

Jezik

engleski

Datum

2023

Licenca

© All rights reserved

Predmet

Keywords : BHK-21/C13, repurposed drugs, fibrosarcoma, hamsters, NF-kB.

Deo kolekcije (1)

o:28516

Radovi nastavnika i saradnika Državnog univerziteta u Novom Pazaru