Naslov (eng)

Aniticancer mechanisms of repurposed drugs in oncology on hamster model

Autor

Popović, Kosta J.
Popović, Jovan K.
Lalošević, Dušan
Čapo, Ivan
Dolićanin, Zana
Popović, Dušica J.
Miljković, Dejan

Opis (eng)

Abstract: Transcription factor NF-kB acts as an important target in oncology, as most of the molecules formed by transcription of genes trigger cancers. Also, ROS (Reactive Oxygen Species) activity is interconnected with NF-kB and cancer development. To identify NF-kB inhibition and/or ROS stimulation as antitumor mechanisms, we have screened combinations of currently approved non-oncological repurposed drugs that can inhibit hamster fibrosarcoma growth by rescuing cancer development with NF-kB stimulation and/or ROS inhibition.

Jezik

engleski

Datum

2023

Licenca

© All rights reserved

Predmet

Keywords : fibrosarcoma, hamsters, repurposed drugs, NF-kB, ROS.

Deo kolekcije (1)

o:28516

Radovi nastavnika i saradnika Državnog univerziteta u Novom Pazaru