Naslov (eng)

Expression of focal adhesion kinase microrna regulators is related to dedifferentiation in thyroid neoplasia spectrum

Autor

Ignjatović Jocić, Valentina
Janković Miljuš, Jelena
Išić Denčić, Tijana
Živaljević, Vladan
Tatić, Svetislav
Đorić, Ilona
Šelemetjev, Sonja

Publisher

Opis (eng)

ABSTRACT The specter of malignant thyroid lesions comprises tumors with different degrees of differentiation, rendering the differential diagnosis and prognosis of these tumors challenging. Focal adhesion kinase (FAK) is a tyrosine kinase involved in cellular communication and locomotion, functioning as a hub in the interactome of focal adhesions. Its upregulation has been demonstrated in a number of tumor types including thyroid cancer. FAK is regulated on several levels, one of which includes posttranscriptional inhibition by microRNAs among which are miR-7-5p, miR-135a-5p, and miR-138-5p. Changes in the regulation of FAK can disturb its activation and indirectly influence malignant transformation and cancer progression.

Jezik

engleski

Datum

2023

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

Focal adhesion kinase, microRNA, thyroid tumor

Deo kolekcije (1)

o:25140

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