Naslov (eng)

Overexpression of activated focal adhesion kinase correlates with adverse clinicopathological factors of papillary thyroid carcinoma

Autor

Ignjatović Jocić, Valentina
Janković Miljuš, Jelena
Rončević, Jelena
Tatić, Svetislav
Išić Denčić, Tijana
Đorić, Ilona
Šelemetjev, Sonja

Publisher

Opis (eng)

ABSTRACT Focal adhesion kinase (FAK) is non-receptor tyrosine kinase that has been shown to affect cell motility, adhesion, invasion, cell survival, proliferation and dedifferentiation. Its increased expression has been reported for various types of malignancies and is associated with cancer progression. However, there are less information regarding its posttranslational form, phosphorylated at Tyrosine 397 (pY397-FAK), which represents a key event for complete protein activation. In order to determine the possible role of the activated form of FAK in progression of papillary thyroid carcinoma (PTC), we analyzed expression levels of pY397-FAK. We aimed to investigate its presence in tumor and adjacent normal thyroid tissue and its localization in tumor cells, as well as its expression levels in relation to clinicopathological parameters of PTC patients.

Jezik

engleski

Datum

2023

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

Focal adhesion kinase, papillary thyroid carcinoma

Deo kolekcije (1)

o:25140

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