Complementarity of miR-203-3p and ETS-1 sequences may influence aggressiveness of papillary thyroid carcinoma
Stojanović, Stefana
Šelemetjev, Sonja
Đorić, Ilona
Janković Miljuš, Jelena
Živaljević, Vladan
Milinković, Marija
Išić Denčić, Tijana
ABSTRACT Papillary thyroid carcinoma (PTC) is the most frequent endocrine tumor, with large variability in histological features and clinical outcomes. Therefore, novel indicators for identifying high-risk PTC patents are constantly required. In order to determine the prognostic value of ETS-1 in PTC patients, ETS-1 protein levels in divergent cell compartments were associated with known clinicopathological parameters of PTC patients. Furthermore, cytoplasmic ETS-1 levels, paired with miR-203a-3p levels, were linked to the incidence of unfavorable clinical characteristics of the patients.
engleski
2023
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cancer biomarker, prognostic factor, microRNA, subcellular localization