Naslov (eng)

Trophoblast Cell Function in the Antiphospholipid Syndrome

Autor

Vrzić Petronijević, Svetlana
Vilotić, Aleksandra
Bojić-Trbojević, Žanka
Kostić, Sanja
Petronijević, Miloš
Vićovac, Ljiljana
Jovanović Krivokuća, Milica

Publisher

Opis (eng)

ABSTRACT Antiphospholipid syndrome (APS) is a complex thrombo-inflammatory autoimmune disease characterized by the presence of antiphospholipid antibodies (aPL).Women with APS are at high risk of recurrent early pregnancy loss as well as late obstetrical complications—premature birth due to placental insufficiency or severe preeclampsia. Accumulating evidence implies that vascular thrombosis is not the only pathogenic mechanism in obstetric APS, and that the direct negative effect of aPL on the placental cells, trophoblast, plays a major role. In this review, we summarize the current findings regarding the potential mechanisms involved in aPL-induced trophoblast dysfunction. Introduction on the APS and aPL is followed by an overview of the effects of aPL on trophoblast—survival, cell function and aPL internalization. Finally, the implication of several non-coding RNAs in pathogenesis of obstetric APS is discussed, with special emphasis of their possible role in trophoblast dysfunction and the associated mechanisms.

Jezik

engleski

Datum

2023

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

antiphospholipid syndrome; antiphospholipid antibodies; placenta; trophoblast; ncRNA

Deo kolekcije (1)

o:25140

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