Naslov (eng)

Significance of 1,25-dihydroxyvitamin D3 on overall mortality in peritoneal dialysis patients with COVID-19

Autor

Baralić, Marko
Robajac, Dragana
Penezić, Ana
Brković, Voin
Gligorijević, Nikola
Bontić, Ana
Pavlović, Jelena
Nikolić, Jelena
Miljuš, Goran
Dobrijević, Zorana
Šunderić, Miloš
Pažitna, Lucia
Katrlik, Jaroslav
Nedić, Olgica
Laušević, Mirjana

Publisher

Opis (eng)

ABSTRACT In previous publications, we pointed out the importance of mannosylation of fibrinogen for the development of cardiovascular complications and fucosylation as a predictor of peritoneal membrane dysfunction in patients on peritoneal dialysis (PD). After a follow-up period of 30 months from the onset of the COVID-19 pandemic, we evaluated the significance of 1,25-dihydroxyvitamin D3 (calcitriol) therapy, primary disease, biochemical and hematologic analyzes, and previously performed glycan analysis by lectin-based microarray as predictors of mortality in this patient group. After univariate Cox regression analysis, diabetes mellitus (DM) and calcitriol therapy were found to be potential predictors of mortality. Additional multivariate Cox regression analysis confirmed that only DM was a predictor of mortality. Nevertheless, the use of calcitriol in therapy significantly reduced mortality in this patient group, as shown by the Kaplan–Meier survival curve. The presence of DM as a concomitant disease proved to be a strong predictor of fatal outcome in PD patients infected with SARS-CoV-2. This is the first study to indicate the importance and beneficial effect of calcitriol therapy on survival in PD patients with COVID-19 infection. In addition, this study points to the possibility that adverse thrombogenic events observed in PD patients during the pandemic may be caused by aberrant fibrinogen glycosylation.

Jezik

engleski

Datum

2023

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

calcitriol, COVID-19, peritoneal dialysis, glycosylation, mortality

Deo kolekcije (1)

o:25140

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