Naslov (eng)

Synthesis of new Pt(II) complex bearing organoselenium ligands and evaluation of citotoxic activity of some structurally related Pt(II) and Pd(II) complexes

Autor

Radenković, Ninko
Kostić, Marina D.
Đorđević, Nataša Z.
Dolićanin, Zana C.
Soldatović, Tanja V.
Živanović, Marko N.
Divac, Vera M.

Opis (eng)

Abstract: Herein we report the synthesis of a new trans-bis(2-phenylselenylmethyl)oxolane)dichloroplati-num(II) complex (Pt1). This newly synthesized complex, together with two structurally related trans-Pd(II) complexes, (trans-bis(2-(phenylselenylmethyl)oxolane) dichloropalladium(II) (Pd1) and trans-bis(2-(phenylselenylmethyl)oxane)dichloropalladium(II) (Pd2), were screened for cytotoxic activity through in vitro studies on the HCT-116 colorectal carcinoma cell line and MRC-5 healthy lung pleura cell line. The activity of the complexes was assessed by comparing it to cisplatin. The cells’ viability and proliferation were determined using an MTT (Microculture Tetrazolium Test) assay.

Jezik

engleski

Datum

2020

Licenca

© All rights reserved

Predmet

Keywords: organoselenium chemistry; palladium; platinum; cytotoxic activity; colon carcinoma

Deo kolekcije (1)

o:28516

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