Naslov (eng)

Galectins in early pregnancy and pregnancy-associated pathologies

Autor

Jovanović Krivokuća, Milica
Bojić-Trbojević, Žanka
Dekanski, Dragana
Legner, Janko
Ćujić, Danica
Pirković, Andrea
Nacka-Aleksić, Mirjana
Vilotić, Aleksandra

Publisher

Opis (eng)

ABSTRACT Galectins are a family of conserved soluble proteins defined by an affinity for β- galactoside structures present on various glycoconjugates. Over the past few decades, galectins have been recognized as important factors for successful implantation and maintenance of pregnancy. An increasing number of studies have demonstrated their involvement in trophoblast cell function and placental development. In addition, several lines of evidence suggest their important roles in feto-maternal immune tolerance regulation and angiogenesis. Changed or dysregulated galectin expression is also described in pregnancy-related disorders. Although the data regarding galectins clinical relevance are still at an early stage, evidence suggests that some galectin family members are promising candidates for better understanding pregnancy-related pathologies, as well as predicting biomarkers. In this review, we aim to summarize current knowledge of galectins in early pregnancy as well as in pregnancy-related pathologies.

Jezik

engleski

Datum

2021

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

galectins, trophoblast function, pregnancy, pregnancy related pathologies

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP