Naslov (eng)

Surface-modified ZrO2 nanoparticles with caffeic acid: characterization and in vitro evaluation of biosafety for placental cells

Autor

Lazić, Vesna
Nedeljković, Jovan M.
Jovanović Krivokuća, Milica
Dekanski, Dragana
Janković-Častvan, Ivona
Ahrenkiel, S. Phillip
Papan, Jelena
Marković, Jelena
Sredojević, Dušan
Pirković, Andrea

Publisher

Opis (eng)

ABSTRACT The toxicity of hybrid nanoparticles, consisting of non-toxic components, zirconium dioxide nanoparticles (ZrO2 NPs), and caffeic acid (CA), was examined against four different cell lines (HTR-8 SV/Neo, JEG-3, JAR, and HeLa). Stable aqueous ZrO2 sol, synthesized by forced hydrolysis, consists of 3–4 nm in size primary particles organized in 30–60 nm in size snowflake-like particles, as determined by transmission electron microscopy and direct light scattering measurements. The surface modification of ZrO2 NPs with CA leads to the formation of an interfacial charge transfer (ICT) complex followed by the appearance of absorption in the visible spectral range. The spectroscopic observations are complemented with the density functional theory calculations using a cluster model. The ZrO2 NPs and CA are non-toxic against four different cell lines in investigated concentration range. Also, ZrO2 NPs promote the proliferation of HTR-8 SV/Neo, JAR, and HeLa cells. On the other hand, hybrid ZrO2/CA NPs induced a significant reduction of the viability of the JEG-3 cells (39 %) for the high concentration of components (1.6 mM ZrO2 and 0.4 mM CA).

Jezik

engleski

Datum

2021

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-ND 4.0 - Creative Commons Autorstvo - Nekomercijalno - Bez prerada 4.0 International License.

http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode

Predmet

toxicity, ZrO2 nanoparticles, caffeic acid, interfacial charge transfer complex, DFT calculations

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP