Naslov (eng)

Molecular mechanisms of possible action of phenolic compounds in COVID-19 protection and prevention

Autor

Gligorijević, Nikola
Ćirković-Veličković, Tanja
Stanić-Vučinić, Dragana
Khulal, Urmila
Stojadinović, Marija
Nedić, Olgica
Radomirović, Mirjana

Publisher

Opis (eng)

ABSTRACT The worldwide outbreak of COVID-19 was caused by a pathogenic virus called Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Therapies against SARS-CoV-2 target the virus or human cells or the immune system. However, therapies based on specific antibodies, such as vaccines and monoclonal antibodies, may become inefficient enough when the virus changes its antigenicity due to mutations. Polyphenols are the major class of bioactive compounds in nature, exerting diverse health effects based on their direct antioxidant activity and their effects in the modulation of intracellular signaling. There are currently numerous clinical trials investigating the effects of polyphenols in prophylaxis and the treatment of COVID-19, from symptomatic, via moderate and severe COVID-19 treatment, to anti-fibrotic treatment in discharged COVID-19 patients. Antiviral activities of polyphenols and their impact on immune system modulation could serve as a solid basis for developing polyphenol-based natural approaches for preventing and treating COVID-19.

Jezik

engleski

Datum

2021

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

SARS-CoV-2, polyphenols, antiviral effects, antiviral targets

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP