Naslov (eng)

Extracellular vesicles and acute kidney injury: potential therapeutic avenue for renal repair and regeneration

Autor

Kosanović, Maja
Ortiz, Alberto
Božić, Milica
Morlans, Ingrid Mena
Glamočlija, Sofija
Milutinović, Bojana

Publisher

Opis (eng)

ABSTRACT Acute kidney injury (AKI) is a sudden decline of renal function and represents a global clinical problem due to an elevated morbidity and mortality. Despite many efforts, currently there are no treatments to halt this devastating condition. Extracellular vesicles (EVs) are nanoparticles secreted by various cell types in both physiological and pathological conditions. EVs can arise from distinct parts of the kidney and can mediate intercellular communication between various cell types along the nephron. Besides their potential as diagnostic tools, EVs have been proposed as powerful new tools for regenerative medicine and have been broadly studied as therapeutic mediators in different models of experimental AKI. In this review, we present an overview of the basic features and biological relevance of EVs, with an emphasis on their functional role in cell-to-cell communication in the kidney. We explore versatile roles of EVs in crucial pathophysiological mechanisms contributing to AKI and give a detailed description of the renoprotective effects of EVs from different origins in AKI. Finally, we explain known mechanisms of action of EVs in AKI and provide an outlook on the potential clinical translation of EVs in the setting of AKI.

Jezik

engleski

Datum

2022

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY 4.0 - Creative Commons Autorstvo 4.0 International License.

http://creativecommons.org/licenses/by/4.0/legalcode

Predmet

extracellular vesicles, exosomes, microvesicles, cellular communication, acute kidney injury, therapeutic agents, renoprotection, mesenchymal stem cells, cell-free therapeutic

Deo kolekcije (1)

o:25140

Radovi Instituta za primenu nuklearne energije - INEP