Naslov (eng)

Taxifolin inhibits endovascular differentiation of human trophoblast cells

Autor

Ilić, Gorana
Jovanović Krivokuća, Milica
Vilotić, Aleksandra
Pirković, Andrea

Publisher

Opis (eng)

ABSTRACT Taxifolin (TF) is a bioactive flavonoid with various pharmacological effects including antioxidant, anti-inflammatory, hepatoprotective and anti-cancer activities1. It can be extracted from different coniferous trees, and it is present in various plants used in traditional medicine as well as in different commercially available health-promoting products1. Also, TF can be found in vegetables, fruits and beverages used in everyday diet [1]. Previously, TF showed cytoprotective, antioxidant and anti-inflammatory activity on trophoblast cells, specialized cells of placenta [2,3], but its effect on function of these cells has not yet been studied. Successful pregnancy largely depends on adequate placentation including remodeling of uterine spiral arteries during which extravillous (EVT) trophoblast cells acquire endothelial-like properties.

Jezik

engleski

Datum

2026

Licenca

Ovo delo je licencirano pod uslovima licence
Creative Commons CC BY-NC-SA 4.0 - Creative Commons Autorstvo - Nekomercijalno - Deliti pod istim uslovima 4.0 International License.

http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode

Predmet

taxifolin; extravillous trophoblast; HTR-8/SVneo cells; endovascular differentiation; VE-cadherin; angiogenesis

Deo kolekcije (1)

o:25140

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